Clinical and laboratory variables from medical records were collected. A retrospective chart search was performed on patients admitted in the largest emergency department (ED) of southern Italy for bleeding events occurrence in 2015 (1 January-31 December 2015). Data from Italian real-life are still lacking. After being largely tested in phase III randomized clinical trials, data about efficacy and safety in large real-world observational studies are progressively increasing. Non-vitamin K antagonist oral anticoagulants (NOACs) radically changed the routine clinical practice for thromboembolism prevention and treatment.
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